Symbol Name ID |
Ikzf1
IKAROS family zinc finger 1 MGI:1342540 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating antibody level |
Pancytopenia |
B lymphocytopenia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Lymphoma |
Disease(s) Associated with IKZF1 | ||||||
acute lymphoblastic leukemia | ||||||
common variable immunodeficiency 13 |
Mouse Phenotypes | abnormal B cell apoptosis |
abnormal granulocyte differentiation |
abnormal macrophage differentiation |
decreased B cell proliferation |
increased T cell proliferation |
abnormal thymus morphology |
abnormal thymus development |
abnormal thymus lobule morphology |
abnormal thymus cortex morphology |
thymus cortex hypoplasia |
abnormal thymus medulla morphology |
enlarged thymus |
thymus hypoplasia |
decreased thymocyte number |
decreased DN1 thymic pro-T cell number |
decreased DN2 thymocyte number |
decreased DN3 thymocyte number |
abnormal thymocyte activation |
enlarged spleen |
spleen hyperplasia |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
abnormal erythropoiesis |
abnormal lymphopoiesis |
abnormal B cell differentiation |
decreased immature B cell number |
decreased pre-pro B cell number |
absent pro-B cells |
increased pro-B cell number |
arrested B cell differentiation |
abnormal T cell differentiation |
decreased double-negative T cell number |
decreased double-positive T cell number |
arrested T cell differentiation |
abnormal myelopoiesis |
myeloid hyperplasia |
extramedullary hematopoiesis |
anemia |
decreased bone marrow cell number |
abnormal erythroid progenitor cell morphology |
decreased erythroid progenitor cell number |
increased basophil cell number |
abnormal eosinophil morphology |
abnormal erythroblast morphology |
decreased fetal derived definitive erythrocyte cell number |
decreased erythrocyte cell number |
decreased hematocrit |
decreased hemoglobin content |
increased nucleated erythrocyte cell number |
decreased granulocyte number |
abnormal dendritic cell number |
decreased plasmacytoid dendritic cell number |
abnormal B cell number |
decreased mature B cell number |
absent B-1a cells |
decreased B-1a cell number |
decreased B-1b cell number |
increased B-1 B cell number |
decreased B cell number |
absent B cells |
decreased pre-B cell number |
absent pre-B cells |
increased pre-B cell number |
absent NK cells |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased mature gamma-delta T cell number |
decreased gamma-delta intraepithelial T cell number |
increased gamma-delta T cell number |
decreased T cell number |
absent T cells |
decreased single-positive T cell number |
increased T cell number |
increased single-positive T cell number |
increased macrophage cell number |
reticulocytopenia |
abnormal NK cell morphology |
abnormal spleen morphology |
decreased spleen red pulp amount |
intermingled spleen red and white pulp |
decreased spleen germinal center number |
increased spleen white pulp amount |
abnormal splenic cell ratio |
decreased splenocyte number |
abnormal B cell physiology |
abnormal B cell activation |
decreased IgG3 level |
increased IgG level |
abnormal natural killer cell mediated cytotoxicity |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1m1Btlr/Ikzf1m1Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1m2Btlr/Ikzf1m2Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1m3Btlr/Ikzf1m3Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1plstc/Ikzf1plstc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm1.1Smale/Ikzf1tm1.1Smale | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm1Kast/Ikzf1tm1Kast | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm1Kge/Ikzf1tm1Kge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm2.1Smale/Ikzf1tm2.1Smale | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm2Kge/Ikzf1tm2Kge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1plstc/Ikzf1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1plstc/Ikzf1tm2Kge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ikzf1tm1Kge/Ikzf1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cd79atm1(cre)Reth/Cd79a+ Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu (conditional) |
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Ikzf1tm3Kge/Ikzf1tm3Kge Tg(CD2-icre)4Kio/? (conditional) |
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Ikzf1tm3Kge/Ikzf1tm3Kge Tg(CD19-cre/ERT2)1Cgn/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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